The cell

2022 - 8 - 18

Post cover — Image courtesy of "Parkinson's News Today"

Roadmap of Dopaminergic Neurons in Parkinson's May Aid in Cell... (Parkinson's News Today)

A new roadmap showing the maturation of dopaminergic neurons from human stem cells could potentially optimize Parkinson's cell therapy.

Further analyses revealed that the main nondopaminergic cell type of the final product (day 25) were choroid plexus epithelial cells (CPECs). One such gene, LGI1, was specific to early dopaminergic neuron progenitors — precursor cells — that were positive for the midbrain marker EN1. This potentially influences efficacy and increases the risk of adverse events. In contrast, nondopaminergic populations were first detected on day 11, and continued to emerge at several subsequent stages, including day 25. But research efforts are increasingly focused on cell-based therapy to replace lost dopaminergic neurons — tackling the neurodegenerative disorder’s underlying [cause](https://parkinsonsnewstoday.com/what-causes-parkinsons-disease/). Dopamine is a major chemical messenger in the brain.

Discovering the future of cell research (News-Medical.net)

In this interview, Yael Geva and Andreas Friese talk to AZoNetwork about how OLS and IDEA-bio Medical joined forces to become a powerhouse in the cell ...

Andreas has extensive experience of over a decay in the life science industry, leading sales teams of cell research equipment and cell culture devices. We specialize in automated imaging systems and image analysis software, offering a broad range of biological applications based on the company’s unique algorithms library. Yael is a biotechnology engineer and has been part of IDEA Bio-Medical team since 2015. Essentially, the system increases the throughput without requiring the user to do anything; the process is undertaken automatically. This can be applied to a range of applications, including cancer research, virology, and immunology – essentially, the system supports anything related to the field of cell biology. There is no longer any need to manually work with the oil, but the user still benefits from the high resolution and the brighter contrast with lower, shorter time gaps. [cell research](https://idea-bio.com/), and we are striving to be the chosen partner for our customers in cell research. YG: We are particularly excited about several new features in the Hermes imaging system that we have recently launched. The system is capable of scanning multiwell plates and slides in multiple fluorescence channels and bright field channels. Today, we work closely with IDEA Bio-Medical to find companies within the field that are keen and able to image what we culture in our CERO. [IDEA Bio-Medical](https://idea-bio.com/about-us/our-company/) is an Israeli company. Together, our two organizations create a complete workflow that can provide a pillar of support for the market.

Researchers uncover the key to maintaining immunity against ... (The Peter Doherty Institute for Infection and Immunity)

Researchers at the Peter Doherty Institute for Infection and Immunity in collaboration with their colleagues from the Technical University of Munich, ...

[T cells in chronic disease become exhausted and lose their function](https://www.nature.com/articles/s41590-020-0760-z). “We are hopeful that our insights into the mechanisms of T cell invigoration may lead to the development of better targeted immunotherapies to improve outcomes in the context of viral infections and cancer.” “The success or failure of immunotherapy in cancer or chronic infection depends on the quality of the T cell response, and we have been able to pinpoint the precise subset of cells that is crucial in maintaining a good response” says Dr Buchholz. “Without this factor, this population of cells doesn’t form, and the T cells responding to the chronic infection cannot be maintained or respond to checkpoint inhibition.” It has long been known that severe diseases can damage our immune system. “These cells are like the fountain of youth for T cell immunity, allowing exhausted T cells to self-renew and remain functional,” says Dr Kretschmer a postdoctoral researcher in Dr Buchholz’s lab, and co-first author of the study.

Beaudry encourages fans to register as stem cell donors - Edmonton ... (Edmonton Elks)

It was, after all, years earlier that Mike Beaudry submitted a cheek swab as part of a donor registration drive while he was a redshirt freshman quarterback at ...

And for something that’s so simple for a healthy person, it’s just so cool to be able to do it.” You get to see the different side of it, you get to see how people really rely on this,” says Beaudry. After months of searching, match that was prepared to donate was located, and Beuadry’s sister, who is married with two young children, will soon be receiving a stem cell transplant in Calgary. A blood stem cell donation from a healthy donor replaces a recipient patient’s unhealthy stem cells to help heal and re-boost their immune system. That by making a stem cell donation, he could possibly save the life of a 68-year-old male battling lymphoma. Now more than four years later, the Regina native was being told that he was a match.

Unravelling cell biology through artificial intelligence (Drug Target Review)

The artificial intelligence algorithm was able to predict the presence and the location of nuclei in more than 8000 cells.

The algorithm was able to successfully predict the presence and the location of the nuclei in more than 8,000 cells, with almost half of those predictions resulting in a deviation of less than 1 μm from their exact position. “We separated the information related to the nucleus and the fibres in independent databases of images, ensuring that there was not any information about the nucleus found in the images of the fibres, so that the system could not cheat. To do so, the system had to take the qualitative data and figure out on its own if there was a relation between the organisation of the fibres and the position of the nucleus.

Unlocking cell nucleus behaviors: Deformation mechanics may be ... (Science Daily)

A team has uncovered surprising mechanical behaviors of the nucleus. For years, the nucleus within a cell was thought to be elastic like a rubber ball, ...

The discovery suggests that lamin A/C helps maintain the surface tension of the "nuclear drop." "Our work points to a fundamental mechanism by which the nucleus preserves its shape and protects its genome," Lele said. The work is financially supported by a grant from the National Cancer Institute's Physical Sciences -- Oncology Network to Lele, along with additional support from the National Science Foundation to co-principal investigator Dr. In order for the cells to crawl through this obstacle course, their nuclei had to squeeze in between the pillars. The genetic material governing a cell's function and behavior, called the genome, is safely stored in the nucleus. For years, the nucleus within a cell was thought to be elastic like a rubber ball, deforming and snapping back into shape as the cell navigated through pores and between fibers inside the human body.