Dostarlimab

2022 - 6 - 7

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Image courtesy of "Financial Express"

Cancer vanishes from every patient's body in drug trial “miraculously ... (Financial Express)

For the first time, the effectiveness of a womb cancer drug undergoing clinical trial has left everyone shocked. The drug, Dostarlimab, has seemingly cured ...

Although the sample size of the trial is quite small, it definitely proves that Dostarlimab can be a potential cure for one of the most deadly common cancers. Reportedly, all 18 rectal cancer patients were given the same drug and as a result of the treatment, cancer was completely obliterated in every patient. The small group of people suffering from rectal cancer witnessed that their cancer vanished after the experimental treatment.

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Image courtesy of "Outlook India"

Dostarlimab Vanishes Cancer Miraculously In Patients For First ... (Outlook India)

Dostarlimab, a drug was given in a small clinical trial to 18 patients for around six months, and in the end, it was found that cancer had just vanished ...

They were all in similar stages of their cancer - it was locally advanced in the rectum but had not spread to other organs. Speaking to the media outlet, Dr Alan P. Venook, who is a colorectal cancer specialist at the University of California, said that the complete remission in every single patient is “unheard-of”. “There were a lot of happy tears,” she told the New York Times. According to New York Times report, in a small clinical trial, 18 patients were given a drug named Dostarlimab for around six months. Five centuries later, an Indian author won a major literary award in the UK and shared it with her American translator, making it an apt occasion to discuss the status of translation in world literature. For a majority of publishing houses, both indie and big, translation work has to be subsidised.

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Image courtesy of "CBS News"

Every patient in this experimental drug trial saw their cancer ... (CBS News)

In a small study, patients with rectal cancer got six months of immunotherapy treatment — and doctors say their tumors disappeared.

"The treatment targets a subtype of rectal cancer that has the DNA repair system not working. But they say that seeing complete remission in 100% of patients tested is a very promising early signal. It was administered to each patient every three weeks for six months, and it works by exposing cancer cells so the immune system can identify and destroy them. "The implications for quality of life are substantial, especially in those where standard treatment would impact childbearing potential. These same remarkable results would be seen in 14 patients to date. That's when doctors gave her the good news: She was now cancer-free.

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Image courtesy of "NPR"

This experimental drug could change the field of cancer research (NPR)

On how the drug works to treat cancer: This drug is one of a class of drugs called immune checkpoint inhibitors. These are immunotherapy medicines that work not ...

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Image courtesy of "Targeted Oncology"

Dostarlimab Shows Durable Antitumor Activity in GARNET Trial ... (Targeted Oncology)

Dostarlimab monotherapy induced durable antitumor activity in advanced or recurrent endometrial cancer among patients with mismatch repair ...

Dostarlimab in advanced/recurrent (AR) mismatch repair deficient/microsatellite instability–high or proficient/stable (dMMR/MSI-H or MMRp/MSS) endometrial cancer (EC): The GARNET study. In total, 153 patients were enrolled in cohort A1 and 161 patients in cohort A1, of which 143 patients and 156 patients were evaluable for efficacy, respectively. The median duration of response (DOR) was not reached (NR; range, 1.18+ to 47.21+) in cohort A1, and was 19.4 months (range, 2.8-47.18+) in cohort A2. At the annual meeting, Oaknin reported on the efficacy and safety of dostarlimab monotherapy in 2 expansion cohorts from the GARNET study that enrolled patients with advanced/recurrent endometrial cancer—in particular, from the third pre-specified interim analysis. Both indications are approved under accelerated approval based on tumor response rate and durability of response. “For patients with disease progression that occurs on or after first-line therapy, overall survivor is typically less than 1 year and there is no standard second-line therapy. Similarly, time to PR in both cohorts were 2.69 months and 2.79 months. J Clin Oncol. 2022;40(suppl 16):5509. doi:10.1200/JCO.2022.40.16_suppl.5509 Median overall survival (OS) for cohort A1 was NR (95% CI, 27.1-NR), with a probability of OS at 24 months of 60.5% (95% CI, 51.5%-68.4%), compared with a median OS of 16.9 months (95% CI, 13.0-21.8) and probability of 38.4% (95% CI, 32.0%-44.6%) in cohort A2. In cohort A1, median progression-free survival (PFS) was 6.0 months (95% CI, 4.1-18.0), with a probability for PFS at 24 months of 40.1% (95% CI, 31.6%-48.4%). In cohort A2, median PFS was 2.7 months (95% CI, 2.6-2.8), with a probability of 9.4% for PFS at 24 months (95% CI, 5.2%-15.0%). In the trial, patients with endometrial cancer were enrolled in cohort A1 (dMMR/MSI-H) or cohort A2 (MMRp/MSS). Median follow-up for both cohorts was 27.6 months and 33.0 months, respectively. Dostarlimab (Jemperli) monotherapy induced durable antitumor activity in advanced or recurrent endometrial cancer among patients with mismatch repair deficient (dMMR)/microsatellite instability–high (MSI-H) or mismatch repair proficient (MMRp)/mismatch stable (MSS) disease, according to data from 2 expansion cohorts in the GARNET trial (NCT02715284) presented at the 2022 ASCO Annual Meeting.

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Image courtesy of "Livemint"

Cancer cure finally here? New drug Dostarlimab cures all patients in ... (Livemint)

In a small clinical trial, 18 patients took the drug Dostarlimab for six months, and all of them had their cancer vanished.

"It is noteworthy that they were all in similar stages of their cancer. According to doctors, the patients, during the trial, took Dostarlimab every three weeks for six months. According to the New York Times, individuals in the clinical experiment previously received treatments such as chemotherapy, radiation, and invasive surgery, all of which could cause bowel, urinary, and sexual dysfunction.

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Image courtesy of "DNA India"

Explained: What is Rectal cancer? What is Dostarlimab and why did ... (DNA India)

In a clinical trial in the United States, all the participating rectal cancer patients were cured. The medical marvel took place in the country's famous ...

The overall five-year survival rate for rectal cancer is 63 per cent. The rectum is a part of the body's elaborate digestive system. In a clinical trial in the United States, all the participating rectal cancer patients were cured.

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Image courtesy of "NBC New York"

'Never Seen Anything Like This': NYC Doc, Patients Talk New ... (NBC New York)

The doctor behind a breakthrough New York City-based cancer study said that the astounding results are unlike anything he — or anyone — has seen before, as.

Usually, patients with rectal cancer must endure surgery and chemotherapy — but there was no need for either of those after patients took the drug. The results that have their physicians equally as excited, and ready to see how else this drug could help. Doctors want to repeat the results with a larger group, saying its too early to say that the cancer is permanently gone. The patients — 19 in all, including six more that were included Monday and another one Tuesday — participated in a small clinical trial through Manhattan’s Memorial Sloan Kettering. Each had a specific form of rectal cancer, and took an experimental cancer drug called Dostarlimab. The patients don’t need convincing though. Now, all of the 19 are in complete remission, cancer-free with minimal side-effects.

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Image courtesy of "Hindustan Times"

Has cancer cure been finally found? What is Dostarlimab? All you ... (Hindustan Times)

In the first time in history, a small clinical trial in the United States showed 100% eradication of the cancer disease in patients at the Memorial Sloan ...

The average price of a pint of beer in Britain has increased to £3.95 this year from £2.30 in 2008, the FT cited CGA as saying. Notably, all the patients were in the similar stages of cancer and had not spread to other organs. As per experts, cancer is undetectable by physical exam - proving that the drug could be a potential cure for the disease. 3. According to experts, the drug ‘Dostarlimab’ includes laboratory-produced molecules and acts as substitute antibodies in the human body. The patients had reportedly undergone the US trial expecting to have to go through other procedures in the next step. 2. As per the NYT, the 18 patients had undergone various treatments before for cancer including chemotherapy, radiation, and invasive surgery.

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Image courtesy of "TheHealthSite"

Its A Miracle! Cancer Vanishes For Every Patient In Drug Trial Indian ... (TheHealthSite)

Dostarlimab is a drug which is being used for the treatment of cancer of the uterus lining (endometrial cancer). Read on to know more about this drug.

Reportedly, all 18 rectal cancer patients were given the same drug and as a result of the treatment, cancer was completely obliterated in every patient. what is it being used for? - News

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